Search results for "guanine based purine"

INVOLVEMENT OF GUANINE-BASED PURINES IN THE MODULATION OF CHOLINERGIC TRANSMISSION IN MOUSE COLONIC PREPARATIONS

2010

Guanine-based purines affects the enteric cholinergic neurotransmission via a mechanism not involving membrane receptors

2011

Increasing evidence indicate that guanine-based purines, known as modulators of intracellular processes, can exert extracellular effects, raising the possibility of the existence of specific receptors for these compounds. We investigated if guaninebased purine receptors may be present in the rodent gastrointestinal tract modulating intestinal contractility, as the well known adenine-based purine receptors. Experiments were performed in vitro recording spontaneous and neurally-evoked contractile activity, as changes in isometric tension, in mouse distal colon circular muscle. Guanosine up to 3 mM or guanine up to 1 mM, did not affect the spontaneous mechanical activity, but they significantl…